HCG

What is hCG?

hCG, human chorionic gonadotropin, is the hormone the placenta makes in early pregnancy. It is a glycoprotein of about 38 kDa: an alpha subunit shared with LH, FSH and TSH, and a beta subunit of its own. Sugar chains cover much of it.

How does hCG work?

• LH receptor: it binds the same receptor as LH, the LH/CG receptor, in the testes and ovaries.
• Longer lasting: its extra sugar chains slow clearance, so it acts far longer than LH.
• Steroid production: on that receptor it drives testosterone and progesterone production.

What do researchers study it for?

• LH receptor signalling and steroid production
• Ovarian and testicular function
• Comparisons with gonadorelin and kisspeptin-10, which act higher up the chain
• Pairing with hMG in reproductive models

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