Melanotan Il

What is Melanotan II?

Melanotan II (MT-2) is a lab-made peptide based on alpha-MSH, the hormone that darkens skin. Its seven amino acids are closed into a ring by a lactam bridge, which makes it far more potent and stable than alpha-MSH. Researchers at the University of Arizona developed it in the 1990s.

It has never been approved as a medicine.

How does it work?

• MC1R: on pigment cells, it raises melanin, the pigment that darkens skin.
• MC4R: in the brain, it affects appetite and sexual function.
• Not selective: it acts on most melanocortin receptors at once, which is why PT-141, its MC4R-leaning relative, was developed from it.

What do researchers study it for?

• Melanocortin receptor pharmacology
• Pigmentation and melanin production
• Appetite and energy balance through MC4R
• Comparisons with PT-141 and Melanotan 1

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